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The significance of McCune-Albright syndrome in relation to fibrous dysplasia is that it encompasses both multiple bone involvement and endocrine issues. McCune-Albright syndrome is a genetic disorder resulting from a mutation that leads to fibrous dysplasia affecting multiple bones and is often associated with other complications, such as endocrine abnormalities like precocious puberty, hyperthyroidism, and growth hormone excess. This syndrome is distinguished by the presence of café-au-lait spots on the skin and the presence of fibrous dysplasia in several bones, which can significantly impact the individual's health and development.

The association with endocrine dysfunction highlights the multifaceted nature of the syndrome, emphasizing its broader implications beyond just skeletal involvement. Other options do not accurately reflect the scope and implications of McCune-Albright syndrome; for example, single bone involvement would not capture the complexity of the condition, and it is not synonymous with Gardner's syndrome, which has a different pathology and manifestations. Additionally, stating that it leads to no significant clinical manifestations overlooks the considerable effects this syndrome can have on a person's health and quality of life.